Promethazine is metabolized via the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites showing while in the urine.

It is important that Promethazine HCl Oral Remedy is measured having an precise measuring device (see Safeguards-Info for Patients). A family teaspoon is just not an precise measuring device and could lead on to overdosage, particularly when half a teaspoon is to be measured.

Antiemetics usually are not proposed for remedy of uncomplicated vomiting in pediatric individuals, and their use need to be limited to extended vomiting of recognised etiology. The extrapyramidal symptoms which could take place secondary to Promethazine HCl Oral Alternative administration can be confused With all the CNS signs of undiagnosed Main ailment, e.g., encephalopathy or Reye's syndrome. Using Promethazine HCl Oral Answer ought to be avoided in pediatric patients whose signs and indicators might advise Reye's syndrome or other hepatic ailments.

The following significant adverse reactions are explained, or described in better detail, in other sections:

If this SPL is made up of inactivated NDCs listed through the FDA initiated compliance action, they will be specified therefore.

“Medical professional buying” (checking out various prescribers to obtain added prescriptions) is prevalent amongst drug abusers and other people struggling from untreated habit. Preoccupation with obtaining adequate ache reduction can be acceptable actions in the affected person with poor ache Command.

Promethazine HCl occurs as being a white to faint yellow, almost odorless, crystalline powder which little by little oxidizes and turns blue on prolonged publicity to air. It truly is freely soluble in water and soluble in Liquor.

The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate, requiring careful thought of the consequences within the mum or dad drug, codeine, plus the active metabolite, morphine.

Warning need to be exercised when administering Promethazine to pediatric patients two many years of age and older. It is recommended that the bottom productive dose of Promethazine be Employed in pediatric sufferers two years of age and older and concomitant administration of other drugs with respiratory depressant outcomes be prevented.

When the response to an opioid antagonist is suboptimal or only brief in nature, administer additional antagonist as directed through the product or service’s prescribing information and facts. The respiratory depressant effects of promethazine are not reversed by opioid antagonists, which include naloxone.

Will not use a household teaspoon to measure your medication. Chances are you'll accidentally just take too much. You are able to check with your pharmacist for your measuring product you should use and how to measure the proper dose.

The website diagnostic evaluation of individuals using this type of syndrome is complex. In arriving in a analysis, it is crucial to determine conditions where the clinical presentation involves both equally really serious health care illness (e.

Promethazine HCl Oral Answer needs to be utilised through pregnancy provided that the opportunity profit justifies the potential danger into the fetus.

Codeine Carcinogenicity scientific studies were being done with codeine. Two-12 months studies in F344/N rats and B6C3F1 mice were being done to assess the carcinogenic probable of codeine. No evidence of tumorigenicity was noticed in male and female rats at codeine dietary doses as many as 70 and eighty mg/kg/day (around such as fifteen and 20 instances, the MRHD on a mg/m2 foundation, respectively).